Nilotinib as an alternate medication for Imatinib-Resistant CML https://www.genuinedrugs123.com/Blog-134-Nilotinib-as-an-alternate-medication-for-Imatinib-Resistant-CML.aspx - Chronic Myeloid Leukemia or CML forms from the clonal expansion of stem cells (pluripotent hematopoietic) that contains an active fusion gene / protein known as BCR/ABL. This protein shows organized tyrosine activity and enables the leukemic cells to grow and also provide resistance to apoptosis.