Efficacy of Bendamustine in treating Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia Bendamustine hydrochloride is a cytotoxic anti-cancer medication approved by the FDA for the treatment of first line chronic lymphocytic leukemia and relapsed non-Hodgkin Lymphoma. It works by interefering with the cell replication by the double stranded DNA and cross linking single DNA. Source : https://www.genuinedrugs123.com/Blog-138-Efficacy-of-Bendamustine-in-treating-Non-Hodgkin-Lymphoma-and-Chronic-Lymphocytic-Leukemia.aspx